Nuclear Proteins
| Definition: |
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. |
| Notes: |
proteins in the cell nucleus: do not confuse with NUCLEOPROTEINS (proteins conjugated with nucleic acids) |
| Also Called: |
Nucleolar Proteins,Nuclear Protein |
| Previously Indexed: |
Nucleoproteins (1966-1987),Proteins (1966-1987) |
Nuclear Proteins Categories.
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Antigens, Nuclear - Immunologically detectable substances found in the CELL NUCLEUS. |
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Chromosomal Proteins, Non-Histone - Nucleoproteins which in contrast to histones are acid insoluble. They are involved in chromosomal functions; e.g. they bind selectively to DNA, stimulate transcription resulting in tissue-specific RNA synthesis and undergo specific changes in response to various hormones or phytomitogens. |
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Histones - Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each. |
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Nuclear Matrix-Associated Proteins - A broad category of nuclear proteins that are components of or participate in the formation of the NUCLEAR MATRIX. |
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Proliferating Cell Nuclear Antigen - Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types. |
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Protamines - A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692) |
Nuclear Proteins Definitions and Terms
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