Disintegrins
| Definition: |
A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors. |
| Notes: |
polypeptides from snake venom; platelet aggregation inhib |
| Previously Indexed: |
Peptides (1992-1996),Venoms (1992-1994) |
Disintegrins Definitions and Terms
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