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Organothiophosphorus Compounds

Definition:	Compounds containing carbon-phosphorus bonds in which the phosphorus component is also bonded to one or more sulfur atoms. Many of these compounds function as pesticides (e.g., INSECTICIDES, ORGANOTHIOPHOSPHATE).
Notes:	includes organothiophosphates; /antag permitted but consider also CHOLINESTERASE REACTIVATORS; DF: ORGANOTHIOPHOSPHORUS CPDS
Previously Indexed:	Phosphates (1966-1970),Phosphonic Acids (1966-1970),Phosphoric Acids (1968-1970),Phosphorous Acids (1968-1970),Phosphorus (1966-1970)

Organothiophosphorus Compounds Categories.

	Amifostine - A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
	Azinphosmethyl - An organothiophosphorus cholinesterase inhibitor. It has been used as an acaricide and as an insecticide.
	Chlorpyrifos - An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.
	Coumaphos - A organothiophosphorus cholinesterase inhibitor that is used as an anthelmintic, insecticide, and as a nematocide.
	Cystaphos - Proposed as an adjuvant to cancer chemotherapy; may have radiation protective properties.
	Diazinon - A cholinesterase inhibitor that is used as an organothiophosphorus insecticide.
	Dimethoate - An organothiophosphorus cholinesterase inhibitor that is used as a systemic and contact insecticide.
	Disulfoton - An organothiophosphate insecticide.
	Echothiophate Iodide - A potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma.
	Fenitrothion - An organothiophosphate cholinesterase inhibitor that is used as an insecticide.
	Fenthion - Potent cholinesterase inhibitor used as an insecticide and acaricide.
	Fonofos - An organothiophosphorus cholinesterase inhibitor that is used as an insecticide.
	Leptophos - An organothiophosphate insecticide.
	Malathion - A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.
	Parathion - A highly toxic cholinesterase inhibitor that is used as an acaricide and as an insecticide.
	Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester - An organothiophosphorus cholinesterase inhibitor that is used as an insecticide and as a acaricide.
	Phorate - A cholinesterase inhibitor that is used as an insecticide.
	Phosmet - An organothiophosphorus insecticide that has been used to control pig mange.
	Temefos - An organothiophosphate insecticide.
	Thiophosphoric Acid Esters
	Thiotepa - A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).

Organothiophosphorus Compounds Definitions and Terms

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