Nerve Sheath Tumors
| Definition: |
Tumors arising from nerve sheaths formed by SCHWANN CELLS in the peripheral nervous system and by oligodendrocytes in the central nervous system. Malignant peripheral nerve sheath tumors, NEUROFIBROMA, and NEURILEMMOMA are relatively common tumors in this category. |
| Notes: |
neoplasms composed of myelin sheaths, NOT neoplasms located in myelin sheaths: TN 135; coord IM with precoord organ/neopl term (IM); DF: MPMST |
| Also Called: |
Malignant Peripheral Nerve Sheath Tumors,Perineurioma,Peripheral Nerve Sheath Tumors |
Nerve Sheath Tumors Categories.
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Neurofibroma - A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016) |
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Neuroma - A tumor made up of nerve cells and nerve fibers. (Dorland, 27th ed) |
Nerve Sheath Tumors Definitions and Terms
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