Sex Cord-Stromal Tumor
| Definition: |
A malignant neoplasm of the ovary or testis. These tumors differentiate toward sex cords (in embryonic gonads) in the form of female (i.e., granulosa and theca) cells, male (i.e., Sertoli and Leydig) cells, or indifferent elements. In the ovary, sex cord-stromal tumors comprise 5% of all ovarian neoplasms. In the testes, Leydig and Sertoli cell tumors comprise about 5% of all testicular neoplasms, 10% of which behave in a malignant fashion. (From Segen, Dictionary of Modern Medicine, 1992) |
| Notes: |
/blood supply /chem /second /secret /ultrastruct permitted; coord IM with TESTICULAR NEOPLASMS (IM) in male or OVARIAN NEOPLASMS (IM) if in female |
| Previously Indexed: |
Ovarian Neoplasms (1980-1993),Testicular Neoplasms (1981-1993) |
Sex Cord-Stromal Tumor Categories.
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Thecoma - A sex cord-stromal tumor of the postmenopausal ovary that is yellow, large, and unilateral, composed of fascicles of lipid-rich spindle cells interspersed with collagen, reticulin fibers, and hyaline plaques. Thecomas and other estrogen-producing tumors (e.g., granulosa cell tumors) may induce adenomatous hyperplasia of the endometrium or well-differentiated endometrial carcinoma in 3%-20% of the cases. (Segen, Dictionary of Modern Medicine, 1992) |
Sex Cord-Stromal Tumor Definitions and Terms
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