Base Sequence
| Definition: |
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence. |
| Notes: |
IM general only; coord with specific nucleic acid; do not confuse with BASE COMPOSITION: comp = what components & how many, sequ = order in which arranged; for base sequencing, use SEQUENCE ANALYSIS, DNA or SEQUENCE ANALYSIS, RNA; when to index with MOLEC |
| Also Called: |
DNA Sequence,RNA Sequence |
| Previously Indexed: |
Nucleotides/analysis (1966-1970),Polynucleotides (1966-1970),specific nucleic acid (1966-1970) |
Base Sequence Categories.
 |
AT Rich Sequence - A nucleic acid sequence that contains an above average number of ADENINE and THYMINE bases. |
|
GC Rich Sequence - A nucleic acid sequence that contains an above average number of GUANINE and CYTOSINE bases. |
|
Matrix Attachment Regions - Regions of the CHROMATIN or DNA that bind to the NUCLEAR MATRIX. They are found in INTERGENIC DNA, especially flanking the 5' ends of genes or clusters of genes. Many of the regions that have been isolated contain a bipartite sequence motif called the MAR/SAR recognition signature sequence that binds to MATRIX ATTACHMENT REGION BINDING PROTEINS. |
|
Regulatory Sequences, Nucleic Acid - Nucleic acid sequences involved in regulating the expression of genes. |
|
Repetitive Sequences, Nucleic Acid - Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occuring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted. |
Base Sequence Definitions and Terms
MedicalGlossary.org is designed as a free, browsable resource for all. The medical terms and definitions are not intended to replace medical informaion provided by licensed healthcare professionals. Please see a doctor if you need medical assistance. Don't see the medical term you were researching? Send us an e-mail from our "about us" page. We will do our best to research and classify new medical terms in a timely manner. Our current list of medical terms is over 26,000. Data sources include the U.S. National Library of Medicine, 2004 Medical Subject Headings.
|
