Mice, Mutant Strains
| Definition: |
Mice bearing mutant genes which are phenotypically expressed in the animals. |
| Notes: |
GEN or unspecified; prefer specifics; NIM when exper animal: no qualif; when IM, qualif permitted; do not forget also to check tag MICE |
Mice, Mutant Strains Categories.
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Mice, Biozzi - A strain of mice bred specifically as high or low antibody responders. |
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Mice, Jimpy - Myelin-deficient mutants which are from the inbred Tabby-Jimpy strain. |
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Mice, Knockout - Mice whose genome contains a gene whose function has been disrupted, or "knocked-out". A common method of producing disabled genes using recombinant DNA technology is by inserting an antibiotic resistance gene into the normal DNA sequence of a clone of the gene being studied. This disrupts the gene's action, thereby preventing it from making an active protein product. Cells in which this transfer is successful are then injected into mouse embryos, producing chimeric mice. These mice are bred to yield a strain in which all the cells contain the knocked-out gene. Knockout mice are used as animal models for various diseases, such as cystic fibrosis, and are helping to clarify the functions of the genes studied within the fields of immunology, cancer genetics, and developmental biology. |
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Mice, Neurologic Mutants - Mice which carry mutant genes for neurologic defects or abnormalities. |
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Mice, Nude - Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses. |
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Mice, Obese - Mutant mice exhibiting a marked obesity coupled with overeating, hyperglycemia, hyperinsulinemia, marked insulin resistance, and infertility when in a homozygous state. They may be inbred or hybrid. |
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Mice, Quaking - Mice homozygous for the mutant autosomal recessive gene, quaking (qk), associated with disorder in myelin formation and manifested by axial tremors. |
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Mice, SCID - Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice. |
Mice, Mutant Strains Definitions and Terms
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