Pharmacokinetics
| Definition: |
Dynamic and kinetic mechanisms of exogenous chemical and drug absorption, biotransformation, distribution, release, transport, uptake, and elimination as a function of dosage, and extent and rate of metabolic processes. It includes toxicokinetics, the pharmacokinetic mechanism of the toxic effects of a substance. |
| Notes: |
GEN or unspecified; no qualif; prefer /pharmacokin with drugs: Manual 19.7+, 19.8.53, 19.10+; DF: PHARMACOKIN |
| Also Called: |
Toxicokinetics |
| Previously Indexed: |
Kinetics (1966-1987),specific Category D heading/metabolism (1966-1987) |
Pharmacokinetics Categories.
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Biotransformation - The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alteration may be either non-synthetic (OXIDATION-REDUCTION; HYDROLYSIS) or synthetic (glucuronide formation, sulfate conjugation, ACETYLATION; METHYLATION). This also includes metabolic detoxication and clearance. |
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Tissue Distribution - Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios. |
Pharmacokinetics Definitions and Terms
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