Giant Cells, Langhans
| Definition: |
Multinucleated cells (fused macrophages) seen in granulomatous inflammations such as tuberculosis, syphilis, sarcoidosis, and deep fungal infections. They resemble foreign-body giant cells (GIANT CELLS, FOREIGN BODY) but Langhans giant cells contain less chromatin and their nuclei are arranged peripherally in a horseshoe-shaped pattern. Langhans giant cells occur frequently in delayed hypersensitivity. |
| Notes: |
a type of macrophage; do not confuse with LANGERHANS CELLS (cutaneous) nor with ISLETS OF LANGERHANS (pancreatic); A 11 qualif |
| Previously Indexed: |
Granuloma, Giant Cell (1977-1989),Macrophages (1966-1989) |
Giant Cells, Langhans Definitions and Terms
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