Nerve Growth Factors
| Definition: |
Factors which enhance the growth potentialities of sensory and sympathetic nerve cells. |
| Notes: |
NERVE GROWTH FACTOR is also available |
| Also Called: |
Growth-Associated Proteins, Neuronal,Neurite Outgrowth Factors |
Nerve Growth Factors Categories.
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Brain-Derived Neurotrophic Factor - A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994) |
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Ciliary Neurotrophic Factor - A neurotrophic factor that promotes the survival of various neuronal cell types and may play an important role in the injury response in the nervous system. |
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Glia Maturation Factor - A factor identified in the brain that influences the growth and differentiation of NEURONS and NEUROGLIA. Glia maturation factor beta is the 17 kD polypeptide product of the GMFB gene and is the principal component of GLIA MATURATION FACTOR. |
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Nerve Growth Factor - NERVE GROWTH FACTOR is the first of a series of neurotrophic factors that were found to influence the growth and differentiation of sympathetic and sensory neurons. It is comprised of alpha, beta, and gamma subunits. The beta subunit is responsible for its growth stimulating activity. |
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Neuregulins - A family of peptides originally found as factors that stimulate the phosphorylation of the erbB-2 receptor (RECEPTORS, ERBB-2). Multiple variant forms of NEUREGULINS occur due to alternative splicing of their mRNAs. The NEUREGULINS include products from the three known genes (NGR1; NGR2 and NGR3). |
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Neurotrophin 3 - A neurotrophic factor involved in regulating the survival of visceral and proprioceptive sensory neurons. It is closely homologous to nerve growth factor beta and BRAIN-DERIVED NEUROTROPHIC FACTOR. |
Nerve Growth Factors Definitions and Terms
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