Vinca Alkaloids
| Definition: |
A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS. |
| Previously Indexed: |
Alkaloids (1966-1972) |
Vinca Alkaloids Categories.
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Vinblastine - Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) |
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Vincamine - A major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders. |
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Vincristine - Antitumor alkaloid isolated from Vinca Rosea. (Merck, 11th ed.) |
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Vindesine - Vinblastine derivative with antineoplastic activity against acute leukemia, lung cancer, carcinoma of the breast, squamous cell carcinoma of the esophagus, head, and neck, and Hodgkin's and non-Hodgkin's lymphomas. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols. |
Vinca Alkaloids Definitions and Terms
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