Lymphocyte Activation
| Definition: |
Morphologic alteration of small lymphocytes in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS, MITOGENS such as PHYTOHEMAGGLUTININS, and by specific antigens. It may also occur in vivo, as in GRAFT REJECTION and chronic myelogenous leukemia (LEUKEMIA, MYELOID, CHRONIC). |
| Notes: |
lymphocyte transformation test goes here but do not index under specific agent inducing transformation unless particularly discussed; do not use for neoplastic or viral transformation of lymphocytes; DF: LYMPHOCYTE TRANSFORM |
| Previously Indexed: |
Lymphocytes/immunology (1966-1968) |
Lymphocyte Activation Definitions and Terms
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