Immune Complex Diseases
| Definition: |
Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides SERUM SICKNESS and the ARTHUS REACTION, evidence supports a pathogenic role for immune complexes in many other systemic immunologic diseases including GLOMERULONEPHRITIS, systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC) and POLYARTERITIS NODOSA. |
| Notes: |
dis caused by deposition of antigen-antibody complexes with resultant damage to tissue; "immune complex" = IMMUNE COMPLEX see ANTIGEN-ANTIBODY COMPLEX |
| Previously Indexed: |
Immunologic Diseases (1971) |
Immune Complex Diseases Categories.
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Arthus Reaction - A dermal inflammatory reaction produced under conditions of antibody excess, when a second injection of antigen produces intravascular antigen-antibody complexes which bind complement, causing cell clumping, endothelial damage, and vascular necrosis. |
Immune Complex Diseases Definitions and Terms
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