Pyrazoles
| Definition: |
|
| Notes: |
includes pyrazolines & pyrazolidines |
Pyrazoles Categories.
 |
Aminopyrine - A drug with analgesic, anti-inflammatory, and antipyretic properties but, owing to the risk of agranulocytosis, whose use is discouraged. (From Martindale, The Extra Pharmacopoeia, 30th ed, p3) |
|
Antipyrine - An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29) |
|
Betazole - A histamine H2 agonist used clinically to test gastric secretory function. |
|
BW-755C - A dual inhibitor of both cyclooxygenase and lipoxygenase pathways. It exerts an anti-inflammatory effect by inhibiting the formation of prostaglandins and leukotrienes. The drug also enhances pulmonary hypoxic vasoconstriction and has a protective effect after myocardial ischemia. |
|
Epirizole - 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine. A pyrimidinyl pyrazole with antipyretic, analgesic, and anti-inflammatory activity. |
|
Indazoles |
|
Muzolimine - A pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide because of severe neurological effects. |
|
Oxypurinol - A xanthine oxidase inhibitor. |
|
Phenylbutazone - A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822) |
Pyrazoles Definitions and Terms
MedicalGlossary.org is designed as a free, browsable resource for all. The medical terms and definitions are not intended to replace medical informaion provided by licensed healthcare professionals. Please see a doctor if you need medical assistance. Don't see the medical term you were researching? Send us an e-mail from our "about us" page. We will do our best to research and classify new medical terms in a timely manner. Our current list of medical terms is over 26,000. Data sources include the U.S. National Library of Medicine, 2004 Medical Subject Headings.
|
