Oxazoles
| Definition: |
Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position. |
| Notes: |
includes oxazolines, oxazolidines |
| Also Called: |
Munchnones |
Oxazoles Categories.
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Aminorex - An amphetamine-like anorectic agent. It may cause pulmonary hypertension. |
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Dimethadione - An anticonvulsant that is the active metabolite of TRIMETHADIONE. |
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Fura-2 - A fluorescent calcium chelating agent which is used to study intracellular calcium in many tissues. The fluorescent and chelating properties of Fura-2 aid in the quantitation of endothelial cell injury, in monitoring ATP-dependent calcium uptake by membrane vesicles, and in the determination of the relationship between cytoplasmic free calcium and oxidase activation in rat neutrophils. |
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Ibotenic Acid - A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist. |
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Isoxazoles |
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Muscimol - Neurotoxic isoxazole isolated from Amanita muscaria and A. phalloides and also obtained by decarboxylation of IBOTENIC ACID. It is a potent agonist at GABA-A receptors and is used mainly as an experimental tool in animal and tissue studies. |
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Oxadiazoles |
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Oxazolidinones - Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents. |
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Oxazolone - Immunologic adjuvant and sensitizing agent. |
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Pemoline - A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children. |
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Trimethadione - An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378) |
Oxazoles Definitions and Terms
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