Cyclins
| Definition: |
Regulatory proteins that function in the cell cycle to activate maturation promoting factor. They complex with p34cdc2 (PROTEIN P34CDC2), the catalytic subunit of MATURATION-PROMOTING FACTOR, and modulate its protein kinase activity. Cyclins themselves have no enzymatic activity. |
| Notes: |
regulatory proteins; growth substances; do not confuse with the nuclear protein cyclin (PCNA or Proliferating Cell Nuclear Antigen); note specifics |
| Previously Indexed: |
Invertebrate Hormones (1987-1990) |
Cyclins Categories.
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Cyclin A - A 33-kD protein identical to adenovirus E1A-associated protein p60. Cyclin A regulates p33cdk2 and p34cdc2, and is necessary for progression through the S phase of the cell cycle. |
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Cyclin B - A 58-kD protein that is regulated post-transcriptionally and post-translationally in the cell cycle. |
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Cyclin D1 - Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms. |
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Cyclin E - A 50-kD protein that complexes with cdk2 in the late G1 phase of the cell cycle. |
Cyclins Definitions and Terms
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