Mutagenesis
| Definition: |
Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS. |
| Previously Indexed: |
Mutation (1966-1990) |
Mutagenesis Categories.
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DNA Repeat Expansion - An increase number of repeats of a genomic, tandemly repeated DNA sequence from one generation to the next. |
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Gene Duplication - Processes occurring in various organisms by which new genes arise, i.e. the duplication of a single gene. In contiguous gene duplication, the duplicated sequence coexists within the boundaries set by the start and stop signals for protein synthesis of the original, resulting in a larger transcription product and protein at the expense of the prexisting protein. In discrete gene duplication, the duplicated sequence is outside the start and stop signals, resulting in two independent genes (GENES, DUPLICATE) and gene products. Gene duplication may result in a MULTIGENE FAMILY; supergenes or PSEUDOGENES. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed) |
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Sequence Deletion - Deletion of sequences of nucleic acids from the genetic material of an individual. |
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Suppression, Genetic - Mutation process that restores the wild-type PHENOTYPE in an organism possessing a mutationally altered GENOTYPE. The second "suppressor" mutation may be on a different gene, on the same gene but located at a distance from the site of the primary mutation, or in extrachromosomal genes (EXTRACHROMOSOMAL INHERITANCE). |
Mutagenesis Definitions and Terms
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