Ergotamines
| Definition: |
A series of structurally-related alkaloids containing the ergotaman backbone structure. |
| Previously Indexed: |
Ergolines (1969-1974),Ergotamine (1966-1974) |
Ergotamines Categories.
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Bromocriptine - A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion. |
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Dihydroergocornine - A 9,10alpha-dihydro derivative of ERGOTAMINE that contains isopropyl sidechains at the 2' and 5' positions of the molecule. |
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Dihydroergocristine - A 9,10alpha-dihydro derivative of ERGOTAMINE that contains an isopropyl sidechain at the 2' position of the molecule. |
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Dihydroergocryptine - A 9,10alpha-dihydro derivative of ERGOTAMINE that contains an isopropyl sidechain at the 2' position and an alpha-isobutyl sidechain at 5'alpha position of the molecule. |
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Dihydroergotamine - A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of migraine. |
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Dihydroergotoxine - A mixture of three different hydrogenated derivatives of ERGOTAMINE: DIHYDROERGOCORNINE, DIHYDROERGOCRISTINE, and DIHYDROERGOCRYPTINE. Dihydroergotoxine has been proposed to be a neuroprotective agent and a nootropic agent. The mechanism of its therapeutic actions is not clear, but it can act as an alpha-adrenergic antagonist and a dopamine agonist. The methanesulfonate salts of this mixture of alkaloids are called ERGOLOID MESYLATES. |
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Ergotamine - A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of MIGRAINE. |
Ergotamines Definitions and Terms
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