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Ergolines

Definition: A series of structurally-related alkaloids that contain the ergoline backbone structure.
Also Called: Ergoline
Previously Indexed: Ergonovine (1966-1968),Ergot Alkaloids (1966-1968),Ergotamine (1966-1968),Lysergic Acid Diethylamide (1966-1968),Methylergonovine (1966-1968),Methysergide (1966-1968)

Ergolines Categories.
Ergonovine - An ergot alkaloid (ERGOT ALKALOIDS) with uterine and vascular smooth muscle contractile properties.
Lisuride - An ergot derivative that acts as an agonist at dopamine D2 receptors (DOPAMINE AGONISTS). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (SEROTONIN AGONISTS).
Lysergic Acid
Metergoline - A dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for MIGRAINE therapy.
Methysergide - An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
Nicergoline - An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease.
Pergolide - A long-acting dopamine agonist which is effective in the treatment of Parkinson's disease and hyperprolactinemia. It has also been observed to have antihypertensive effects.

Ergolines Definitions and Terms

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