Recombinases
| Definition: |
A broad category of enzymes that are involved in the process of GENETIC RECOMBINATION. |
| Also Called: |
Resolvases |
| Previously Indexed: |
DNA Nucleotidyltransferases (1986-2003) |
Recombinases Categories.
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Integrases - Recombinases that insert exogenous DNA into the host genome. Examples include proteins encoded by the POL GENE of RETROVIRIDAE and also by temperate BACTERIOPHAGES, the best known being BACTERIOPHAGE LAMBDA. |
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Rec A Recombinases - Recombinases found primarily in BACTERIA. They catalyze the ATP-driven exchange of DNA strands in genetic recombination. The product of the reaction consists of a duplex and a displaced single-stranded loop, which has the shape of the letter D and is therefore called a D-loop structure. |
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Transposon Resolvases - Recombinases that involved in the propagation of DNA TRANSPOSONS. They bind to transposon sequences found at two different sites along the same stretch of DNA and bring them into close proximity. The enzymes then catalyze the double strand cleavage, exchange of double strands and rejoining of DNA helices so that the DNA transposon is formed into a circular PLASMID. |
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VDJ Recombinases - Recombinases involved in the rearrangement of immunity-related GENES such as IMMUNOGLOBULIN GENES and T-CELL RECEPTOR GENES. |
Recombinases Definitions and Terms
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