Ligases
| Definition: |
A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6. |
| CAS Number: |
EC 6. |
Ligases Categories.
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Carbon-Carbon Ligases - Enzymes that catalyze the joining of two molecules by the formation of a carbon-carbon bond. These are the carboxylating enzymes and are mostly biotinyl-proteins. EC 6.4. |
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Carbon-Nitrogen Ligases - Enzymes that catalyze the joining of two molecules by the formation of a carbon-nitrogen bond. EC 6.3. |
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Carbon-Oxygen Ligases - Enzymes that catalyze the joining of two molecules by the formation of a carbon-oxygen bond. EC 6.1. |
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Carbon-Sulfur Ligases - Enzymes that catalyze the joining of two molecules by the formation of a carbon-sulfur bond. EC 6.2. |
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Polynucleotide Ligases - Catalyze the joining of preformed ribonucleotides or deoxyribonucleotides in phosphodiester linkage during genetic processes. EC 6.5.1. |
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Ubiquitin-Protein Ligase Complexes - Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES). |
Ligases Definitions and Terms
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