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Polyendocrinopathies, Autoimmune
| Definition: |
Autoimmune disease affecting multiple endocrine organs. Type I is characterized by childhood onset and mucocutaneous candidiasis, while type II exhibits any combination of adrenal insufficiency (ADDISON'S DISEASE), lymphocytic thyroiditis, hypoparathyroidism, and gonadal failure. In both types organ-specific antibodies against a variety of endocrine glands have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present. |
| Notes: |
a multiple endocrine disord so do not coord with specific endocrine dis or precoord endocr dis term unless particularly discussed; do not index under CANDIDIASIS unless particularly discussed: see MeSH definition; DF: APECED |
| Also Called: |
Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal-Dystrophy,Polyglandular Type I Autoimmune Syndrome,Autoimmune Syndrome Type II, Polyglandular |
| Previously Indexed: |
Autoimmune Diseases (1968-1991),Endocrine Diseases (1978-1991) |
Polyendocrinopathies, Autoimmune Definitions and Terms
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