Clozapine
| Definition: |
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. |
| Also Called: |
Clozaril,Leponex |
| CAS Type 1 Name: |
CAS Number: |
5786-21-0 |
| Previously Indexed: |
Dibenzazepines (1971-1974),Piperazines (1971-1974) |
Clozapine Definitions and Terms
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