Drug Tolerance
| Definition: |
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL. |
| Notes: |
differentiate from DRUG RESISTANCE; not for tolerability ( = drug /adv eff): Manual 28.19 |
Drug Tolerance Definitions and Terms
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