Cell Line, Tumor
| Definition: |
A cell line derived from cultured tumor cells. |
| Notes: |
almost always NIM with no subheadings; check ANIMALS or HUMAN; do not routinely add neoplasm term; policy Manual 21.57, 22.26.1, 24.4.5 |
| Previously Indexed: |
Cell Line (1969-1989),Tumor Cells, Cultured (1988-2003) |
Cell Line, Tumor Categories.
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Caco-2 Cells - Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells, such as ENTEROCYTES. These cells are valuable in vitro tools for studies related to intestinal cell function and differentiation. |
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HCT116 Cells - Human COLORECTAL CARCINOMA cell line. |
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Hela Cells - The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks (one of several pseudonyms). These cells are used for VIRUS CULTIVATION and antitumor drug screening assays. |
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HL-60 Cells - A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8) |
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HT29 Cells - Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS. |
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Jurkat Cells - A CELL LINE derived from human T-CELL LEUKEMIA and used to determine the mechanism of differential susceptibility to anti-cancer drugs and radiation. |
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K562 Cells - An ERYTHROLEUKEMIA cell line derived from a CHRONIC MYELOID LEUKEMIA patient in BLAST CRISIS. |
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PC12 Cells - A CELL LINE derived from a PHEOCHROMOCYTOMA of the rat ADRENAL MEDULLA. PC12 cells stop dividing and undergo terminal differentiation when treated with NERVE GROWTH FACTOR, making the line a useful model system for NERVE CELL differentiation. |
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U937 Cells - A human cell line established from a diffuse histiocytic lymphoma (HISTIOCYTIC LYMPHOMA, DIFFUSE) and displaying many monocytic characteristics. It serves as an in vitro model for MONOCYTE and MACROPHAGE differentiation. |
Cell Line, Tumor Definitions and Terms
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