Cell Line, Transformed
| Definition: |
Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. It occurs spontaneously or through interaction with viruses, oncogenes, radiation, or drugs/chemicals. |
| Notes: |
almost always NIM with no subheadings; check ANIMALS or HUMAN; do not routinely add tissue or organ |
| Previously Indexed: |
Cell Line (1966-1987),Cell Transformation, Neoplastic (1966-1987),Cell Transformation, Viral (1978-1987),Cells, Cultured (1966-1987),Tissue Culture (1966-1976) |
Cell Line, Transformed Categories.
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COS Cells - CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).) |
Cell Line, Transformed Definitions and Terms
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