Supranuclear Palsy, Progressive
| Definition: |
A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7) |
| Previously Indexed: |
Ophthalmoplegia (1979-1986),Paralysis (1966-1986),Paralysis, Bulbar (1966-1986) |
Supranuclear Palsy, Progressive Definitions and Terms
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